The science of stem cells and their possible applications in the field of regenerative medicines has been a subject of great optimism for treating various debilitating diseases. Since the first hit and trial in 1960’s, there has been a speedy upgradation of technology to acquire stem cells from various sources at different levels of potency. In the sense, these are the cardinal players in the pyramid of human development; with an inherent competence to give rise to cells of different type; specific to a tissue or an organ. Hence stem cells are practically present in each organ as a maintenance support in normal wear and tear of the body.
Stem cells isolated from the umbilical cord tissue are the most attractive sources of all, being easily available, ethically exempted, functionally safe and blessed with nearly the same efficiency as embryonic stem cells. The effective applications of these stem cells in spinal cord injuries, neurodegenerative disorders, blood disorders and autoimmune disorders have been endorsed by various scientists, regulatory bodies and clinical trials. With the technological advancements, it is now possible to bank these stem cells as a total health guarantee of the complete family. Thus, many expectant parents are now routinely storing their baby’s stem cells; to be available for use in existing and future medical treatments.
As cord blood banking gained popularity in the past decade, cord blood and cord tissue are widely collected and stored across the globe. However, storage of amniotic membrane derived from human placental tissue is still overlooked, despite having a broad range of clinical applications in tissue reconstruction. It is a multilayered tissue with epithelial cells, basement membrane and avascular connective tissue matrix.
These autologous amniotic grafts can as well be collected and stored as organic scaffolds. It has the potential to be used as a wound covering for surgical sites, birth marks/scars and tissue defects as in cases of burns and/or severe injuries obviating the need for skin grafting.
It can thus be used as biological foundation for faster regeneration of tissue such as skin that can enhance healing but still maintain the natural structural and biological properties of the tissue.
Amniotic Tissue Allograft: – Features and Benefits
- The graft can be a good source of naturally occurring active growth factors such as fibronectin, integrins, and laminin; helping in resident stem cells stimulation, cellular proliferation and faster differentiation into desired tissue specific cells.
- It is made up of collagen and fibrous proteins that can be used as a good structural support for better cellular adherence, promoting cellular migration and faster reconstruction of the tissue.
- It has been confirmed that these grafts are immune privileged and have immune modulatory effects, thus minimizing the risk of other opportunistic infections.
- The graft supports reduction of inflammation, fibrous tissue growth and potential scar tissue formation, thus have many applications in wound healing, eye disorders and cosmetic procedures.
This proprietary procedure of storing amniotic membrane has been developed by taking into account regulatory issues such as safety, efficacy, sterility and feasibility of separating it gently from other placental tissues. The process involves stringent steps such as cleaning, sterilization, separation and decellularization of the membrane in way that the key elements associated with the healing are preserved with an intact extracellular matrix; before storage. The result is a clear, durable graft that expedites patient’s recovery by reducing inflammation, faster healing, suppressing pain associated with the injury and achieving a superior cosmetic outcome. We are taking care not to add any extra unnecessary chemicals during the process that may cause unwanted effects.
Thus, along with other extra embryonic tissues such as cord blood, cord tissue, etc. Storage of amniotic membranes can be an added advantage to deliver clinically effective and minimally manipulated scaffolds for managing chronic wounds, cosmetic issues and eye problems.