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Stem Cell Treatment for Optic Neuritis

Optic neuritis is a demyelinating inflammation of the optic nerve; that is generally triggered by the immune destruction of surrounding myelin sheath. This demyelination can contribute to the visual disturbances, color blindness and pain in the eyes especially associated with eye movement or dull aching pain behind the eyes. Apparently in more advanced cases, it may indicate optic nerve abnormalities, neural damage, increased neural pressure and neurodegenerative disorders, such as multiple sclerosis. Thus, in fact the optic neuritis may lead to total visual loss, if not treated well in time.

The condition is mostly common in younger adults below 45 years; with suggestive altogether higher incidences in women than in men. In majority of patients, it is either associated with multiple sclerosis (MS) or ischemic optic neuropathy (Blood Clot). Thus besides deliberately promoting visual damage; it can often be related to the neural damage in MS that may be associated with locomotary and sensory functional loss.

As a matter of fact, some of the less common causes of optic neuritis may include:

  • Viral (measles, mumps and herpes) or bacterial infections (Lyme disease, cat-scratch fever and syphilis etc)
  • Sarcoidosis and Lupus
  • Drugs such as Quinine
  • Sinusitis
  • Genetic Predisposition
  • Nutritional deficiency
  • Environmental exposure to toxins

Diagnosis is confirmed by signs which include reduced visual acuity, substantial decrease in the peripheral vision of the patient, reduced sense of colour discrimination and identification of physical abnormality in the pupil of the affected eye confirmed by Slit lamp examination or ophthalmoscope. Visible swelling, blood vessel enlargement and retro bulbar inflammation around the optic nerve are other associated symptoms.
Conventionally, the treatment of MS associated optic neuritis includes intravenous administration of steroidal medications with the notion to reduce optic nerve inflammation; however studies have reported various possible side effects, such as weight gain, mood swings, facial flushing, stomach upset, and sleep apnea. Moreover, long term exposure may dangerously promote organ damage or hormonal disturbances.
Conventional treatment with steroidal medications is associated with numerous side effects. A science of stem cells has a precise solution to limit those challenges; by maximizing neural regeneration, reduction in the inflammation causing glial cell damage and promoting the production of oligodendrocytes.
Stem cells are the naive cells in the body with the potential to differentiate into multiple cells of different lineages or origin. Accordingly, mesenchymal stem cells isolated from human umbilical cord have been reported to be the most potent cells, exhibiting anti inflammatory, immunomodulatory and angiogenic ability. The vast database generated from worldwide clinical studies have raised hope of millions of people, that stem cells therapy can be employed successfully to treat patients with optic neuritis and associated conditions. These cells are reportedly contributing to the stimulation of endogenous stem cells, once infused inside the body; in order to enforce prompt repair and regeneration of lost cells to restore back the function.
Thus, a unique approach of treating degenerative disorders like Optic Neuritis with the help of allogenic administration of mesenchymal stem cells have definitely proven to be very critical in transforming bench side discovery into beneficial therapy.

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Autism Treatment

Autism Treatment

autism treatment

What is Autism Spectrum Disorder?

Autism spectrum disorder (ASD) and autism are commonly used terms for a group of Neuro-development disorder (related to brain development). These disorders are associated with various characteristics as social interaction and repetitive behavior. As per various studies, autism appears to have its roots in very early brain development and obvious signs of autism tend to emerge between 2 and 3 years of age.

Globally, autism is estimated to affect 21.7 million people as of 2013.As of 2010, the number of people affected was estimated at about 1–2 per 1,000 worldwide. It occurs four to five times more often in boys than girls. (http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60692-4/abstract)

Causes of Autism?

There is no one cause of autism just as there is no one type of autism. As per the research in this area most cases of autism, appear to be caused by a combination of autism risk genes and environmental factors influencing early brain development. Environmental factors which have been claimed to contribute to or worsen the autism condition are certain foods, infectious diseases, pesticides, alcohol, smoking, illicit drugs, prenatal stress, air pollution especially heavy metals and particulates. (http://www.niehs.nih.gov/health/topics/conditions/autism/index.cfm)

Autism Early symptoms includes following mentioned pattern or behavior:

  • Unable to engage in everyday social interactions.
  • Verbal and nonverbal communication (do not respond, look or listen to people in their environment).
  • Intellectual disability.
  • Difficulty in motor coordination.
  • Repetitive behaviors.
  • Activities and physical issues as sleep, gastrointestinal disturbances.
  • Little eye contact.
  • Respond unusually when others show anger, distress, or affection.
  • Fail or be slow to respond to their name or other verbal attempts to gain their attention.
  • Fail or be slow to develop gestures, such as pointing and showing things to others.
  • Development of language at a delayed pace.
  • Learn to communicate using pictures or their own sign language.
  • Speak only in single words or repeat certain words or phrases. Unable to combine words into meaningful sentences.
  • Use words that seem out of context for general person but have a special meaning known only to those familiar with the child’s way of communicating.

Stem Cell Treatment:

Stem cell therapy accompanied with other intervention can help in improving the condition of the patient with Autism. Stem cell helps in restoration of nerve cells function and angiogenesis process helps in restoration of blood vessel which in turn helps in supply of oxygen to damaged tissues. Also paracrine activities or growth factors released from stem cells enable cell differentiation and immunomodulation.Due to neural regeneration and better immune responses, stem cells enable cognitive awareness, sensory perception, better language and communication skills, and social/ behavior skills.

Procedure for Treating Autism Using stem Cells:

Procedure for treatment includes Intravenous injection and Lumber puncture. Other intervention depending on the patient’s condition.

Outcome of treatments:

Stem cells can bring in bettercoordination and social behavior in patients undergoing stem cell treatment. These improvementsmay vary from patient to patient and cannot be guaranteed.

  • Standard Documents: Test or doctor’s summary of a brain MRI or CT
  • If Applicable: ADIR, ADOS